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Target intelligence / Profile preview
Type 1 iodothyronine deiodinase (DIO1)
- Target
- DIO1
- Molecular classification
- Enzyme, Selenoenzyme
01
Overview
Type 1 iodothyronine deiodinase (D1) is a selenoenzyme that plays a crucial role in thyroid hormone metabolism. It catalyzes the conversion of thyroxine (T4) to the active hormone triiodothyronine (T3), as well as the inactivation of T4 to reverse T3 (rT3). D1 is primarily expressed in the liver, kidney, thyroid gland, and pituitary gland, and its activity is regulated by thyroid hormones, cytokines, and certain drugs. It is an important therapeutic target for managing thyroid disorders.
- Other names
- DID-IDID_01Iodothyronine deiodinase type I5'-deiodinase5'-DI
02
Mechanism of action
Inhibition of deiodination activity, preventing conversion of T4 to T3 or altering the clearance of inactive iodothyronines.
03
Biological functions
Thyroid hormone metabolismConversion of T4 to T3Inactivation of T4 to rT3Iodothyronine deiodinationRegulation of circulating T3 levelsIodine recycling
04
Disease associations
Thyroid disordersHyperthyroidismHypothyroidismNon-thyroidal illness syndromeCancer (potential role in some cancers)
05
Safety considerations
Drug-induced hypothyroidismDrug-induced hyperthyroidismPotential impact on thyroid hormone balance during drug treatment
06
Interacting drugs
Propylthiouracil (PTU)
3 more in the full profile.
07
Biomarkers
Serum T3 levelsSerum rT3 levelsDIO1 expression levels in tissuesDIO1 genetic polymorphisms
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