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Target intelligence / Profile preview
Type 1 tumour necrosis factor receptor (TNFR1)
- Target
- TNFR1
- Molecular classification
- Receptor, Transmembrane receptor
01
Overview
Type 1 tumour necrosis factor receptor (TNFR1) is a transmembrane receptor that binds to tumor necrosis factor-alpha (TNFα) and regulates inflammatory pathways and immune responses. Upon binding with TNFα, TNFR1 activates intracellular signaling pathways involved in cell survival, apoptosis, and inflammation. It contains a death domain (DD) essential for recruiting adaptor proteins and initiating downstream signaling. Mutations in the TNFRSF1A gene are associated with tumor necrosis factor receptor-associated periodic syndrome (TRAPS). Elevated serum levels of TNFR1 have been linked to conditions such as schizophrenia, bipolar disorder, cognitive impairment, and dementia. TNFR1 plays a complex role in cancer, mediating both anti-tumor and pro-tumor effects. It is constitutively expressed on almost all nucleated cells.
- Other names
- Tumor necrosis factor receptor superfamily member 1ATNFRSF1ACD120a
02
Mechanism of action
TNF-alpha antagonist
03
Biological functions
Signal transductionApoptosisImmune responseCell survivalInflammationCell deathNecroptosis
04
Disease associations
CancerInflammationNeurodegenerative diseaseAutoimmune diseasesTRAPSSchizophreniaBipolar disorderCognitive impairmentDementia
05
Safety considerations
Potential for immune suppressionIncreased risk of infectionExacerbation of certain conditions
06
Biomarkers
Elevated serum levels of TNFR1
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