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Target intelligence / Profile preview
Type-2 Angiotensin II Receptor (AT2)
- Target
- AT2
- Molecular classification
- G protein-coupled receptor, GPCR rhodopsin family, Receptor
01
Overview
The type-2 angiotensin II receptor (AT2), encoded by the AGTR2 gene, is a G protein-coupled receptor (GPCR) that binds angiotensin II. Unlike the AT1 receptor, which mediates vasoconstriction and cell proliferation, the AT2 receptor generally counteracts these effects, promoting vasodilation, anti-proliferation, and apoptosis. It plays a role in cardiovascular and renal regulation and is implicated in various diseases, including hypertension and heart failure. Targeting AT2 therapeutically may offer protective effects against AT1-mediated organ damage.
- Other names
- AGTR2
02
Mechanism of action
Agonist or antagonist binding to AT2 receptor, modulating downstream signaling pathways such as nitric oxide/cGMP signaling, MAPK inhibition, and ion channel regulation.
03
Biological functions
Signal transductionAnti-proliferationApoptosisCell differentiationNeurite outgrowthModulation of ion channel activityRegulation of blood pressureFluid balanceVasodilation
04
Disease associations
HypertensionSecondary hypertensionCardiovascular diseaseMyocardial infarctionHeart failureKidney diseaseObesity-related pathologies
05
Safety considerations
Potential for off-target effects due to cross-reactivity with other GPCRs.Complex interplay with the AT1 receptor, requiring careful consideration of the balance between AT1 and AT2 signaling.Limited clinical data on the long-term safety and efficacy of AT2-targeted therapies.
06
Interacting drugs
Angiotensin II
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