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Type 2 Cyclic Nucleotide Phosphodiesterase (None)
- Target
- None
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Type 2 cyclic nucleotide phosphodiesterases (PDE2) are a subfamily of enzymes that hydrolyze the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), converting them to their respective 5'-monophosphate forms. PDE2 is uniquely activated by the binding of cGMP to an allosteric domain on the enzyme, increasing its hydrolytic activity toward both cAMP and cGMP. They are expressed broadly across many tissue types and play a critical role in modulating signal transduction pathways that control numerous cellular functions.
- Other names
- PDE2
02
Mechanism of action
Phosphodiesterase inhibition
03
Biological functions
Signal transductionRegulation of cAMP levelsRegulation of cGMP levelsCross-talk between nucleotide pathwaysCardiovascular regulationNeuronal signalingHormone secretionImmune cell function
04
Disease associations
Cardiovascular diseaseNeurological disordersImmunological disorders
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