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Target intelligence / Profile preview
Type 2 Fibroblast Growth Factor Receptor (FGFR2)
- Target
- FGFR2
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
Type 2 Fibroblast Growth Factor Receptor (FGFR2), also known as CD332, is a transmembrane receptor tyrosine kinase that plays critical roles in embryonic development, tissue repair, bone formation, angiogenesis, and cell differentiation. It signals through RAS-MAPK, PI3K-AKT, and PLCγ pathways, regulating cell proliferation, survival, and differentiation. Mutations and overexpression of FGFR2 are implicated in various cancers and developmental syndromes, making it a therapeutic target.
- Other names
- CD332
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionCell proliferationCell differentiationAngiogenesisWound healingBone development/remodelingMitogenesisEmbryonic developmentTissue repair
04
Disease associations
CancerGenetic DisordersLADD syndromeSkeletal development disorders
05
Safety considerations
Aberrant cellular outcomes like uncontrolled growth or defective differentiationConstitutive activation leading to abnormal tissue formation
06
Biomarkers
FGFR2 overexpressionFGFR2 amplification
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