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Type 2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase (PIP4P2)

Target: PIP4P2
Molecular classification: Enzyme, Transmembrane protein, Phosphatase (EC 3.1.3.78; Class I Cys-based protein tyrosine phosphatases (PTPs); Family: Dual specificity phosphatases (DSP))

Overview

Type 2 phosphatidylinositol-4,5-bisphosphate 4-phosphatase (PIP4P2) is a transmembrane enzyme localized to late endosome and lysosome membranes, where it catalyzes the removal of the 4-phosphate group from phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2), producing phosphatidylinositol-4-phosphate (PtdIns-4-P)[2][5][6]. It is specific for PI(4,5)P2, does not act on other phosphoinositide forms such as PI(3,4,5)P3 or PI(3,4)P2[2][5]. PIP4P2 negatively regulates phagocytosis and impacts cellular signaling by controlling levels of PI(4,5)P2, which is central to numerous processes, including cytoskeletal dynamics, membrane trafficking, and ion channel regulation[2][4][6]. Genetic variations are associated with inherited neurologic disorders such as spinocerebellar ataxia[2].

Other names: TMEM55ATransmembrane protein 55AType 2 PtdIns-4,5-P2 4-PtasePtdIns-4,5-P2 4-Ptase IIDKFZp762O076type II phosphatidylinositol-4,5-bisphosphate 4-phosphatasetype II PtdIns-4,5-P(2) 4-phosphatase

Biological functions

Phosphoinositide metabolism (hydrolysis of phosphatidylinositol-4,5-bisphosphate to phosphatidylinositol-4-phosphate)Regulation of signal transductionNegative regulation of phagocytosis (by reducing phagosomal PtdIns-4,5-P2 during cup formation)Membrane dynamics (via phosphoinositide signaling)

Disease associations

Spinocerebellar ataxia, autosomal recessive 10Potential involvement in cancer due to its regulatory functions in signaling pathways; further direct links require additional data

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