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Target intelligence / Profile preview
Type 3 Fibroblast Growth Factor Receptor (FGFR3)
- Target
- FGFR3
- Molecular classification
- Receptor, Receptor Tyrosine Kinase, Transmembrane Receptor
01
Overview
FGFR3 is a transmembrane receptor tyrosine kinase that mediates cellular responses to fibroblast growth factors (FGFs). It plays a critical role in bone development, cell proliferation, and differentiation. Gain-of-function mutations are associated with skeletal dysplasias like achondroplasia and certain cancers. Upon ligand binding and dimerization, FGFR3 activates intracellular signaling pathways such as JAK/STAT and PI3K/AKT.
- Other names
- CD333JTK4
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionCell proliferationCell differentiationAngiogenesisWound healingEmbryonic developmentRegulation of endochondral bone growth
04
Disease associations
AchondroplasiaHypochondroplasiaThanatophoric DysplasiaCancerSkeletal Dysplasia
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