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Target intelligence / Profile preview
Fimbriae types 2 and 3 (FIM2/FIM3)
- Target
- FIM2/FIM3
- Molecular classification
- Adhesin, Type 1 pili family member, Fimbriae, Pili
01
Overview
Fimbriae types 2 and 3 (FIM2 and FIM3) are hair-like protein structures found on the surface of certain bacteria, including Bordetella pertussis and Klebsiella pneumoniae. They function as adhesins, mediating bacterial attachment to host tissues or abiotic surfaces, playing a significant role in colonization, biofilm formation, and pathogenesis. In B. pertussis, they are vaccine antigens. In K. pneumoniae, type 3 fimbriae are encoded by the mrkABCDF gene cluster and are crucial for biofilm development.
- Other names
- Agglutinogens 2 and 3Type 2 fimbriaeType 3 fimbriaeMrk fimbriae (Klebsiella pneumoniae)
02
Mechanism of action
Preventing bacterial adhesion to host cells
03
Biological functions
AdhesionColonizationBiofilm formationImmune response
04
Disease associations
InfectionWhooping cough (Bordetella pertussis)Pneumonia (Klebsiella pneumoniae)Urinary tract infections (Klebsiella pneumoniae)Biofilm-associated infections
05
Safety considerations
Potential for off-target effects if adhesion mechanisms are similar to host cell adhesion moleculesDevelopment of resistance or altered fimbrial expression by bacteria
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