Target intelligence / Profile preview

Type 5 Cyclic Nucleotide Phosphodiesterase (PDE5)

Target: PDE5
Molecular classification: Enzyme, Phosphodiesterase

Overview

Type 5 cyclic nucleotide phosphodiesterase (PDE5) is a key regulator of intracellular cGMP levels with major roles in vascular tone regulation and reproductive physiology. It serves as an important drug target due to its tissue distribution profile and regulatory mechanisms that allow selective pharmacological intervention without widespread systemic effects when properly targeted.

Other names: cGMP-specific phosphodiesterase type 5

Mechanism of action

Selective inhibition of PDE5, preventing the breakdown of cGMP

Biological functions

Regulation of cGMP levelsSmooth muscle relaxationVisual signal transduction

Disease associations

Erectile dysfunctionPulmonary hypertensionCardiovascular disease

Safety considerations

Visual disturbances due to cross-reactivity with PDE6Hypotension

Interacting drugs

Sildenafil

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