Type A Natriuretic Peptide Receptor (NPR-A)

Natriuretic peptide receptor A (NPR-A) is a transmembrane receptor that primarily binds atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP). It is a key mediator of the physiological effects of these hormones, which include regulation of blood pressure, blood volume, and cardiovascular homeostasis. Binding of ANP or BNP to the extracellular domain induces conformational changes leading to dimerization and activation. This triggers conversion of GTP to cGMP by the guanylyl cyclase activity in the intracellular domain. Increased cGMP activates downstream effectors such as cGMP-dependent protein kinase G (PKG), leading to vasodilation, diuresis, natriuresis, and inhibition of cell proliferation/apoptosis/inflammation.

Other names

Guanylyl cyclase-AGC-AANP receptor ANPR1

Activation of guanylyl cyclase, leading to increased cGMP production and downstream signaling via PKG.