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Type I Interferon Receptor Subunit 1 (None)
- Target
- None
- Molecular classification
- Receptor, Type I cytokine receptor
01
Overview
IFNAR1 (Interferon alpha and beta receptor subunit 1) is a type I membrane protein that forms one of the two essential subunits of the type I interferon receptor complex, partnering with IFNAR2. It binds all type I interferons and upon ligand binding, the receptor chains dimerize, activating JAKs and leading to STAT protein phosphorylation and subsequent transcription of interferon-stimulated genes. It plays a crucial role in antiviral defense and immunomodulation.
- Other names
- AVPIFN-alpha-RECIFNARIFNBRIFRC
02
Mechanism of action
Binding to IFNAR1/IFNAR2 heterodimer, activation of JAK/STAT pathway, induction of interferon-stimulated genes (ISGs)
03
Biological functions
Signal transductionAntiviral response inductionImmunomodulationRegulation of immune cell activationRegulation of immune cell growthRegulation of immune cell proliferationRegulation of immune cell differentiationRegulation of immune cell viability
04
Disease associations
InfectionAutoimmune diseasesCancer
05
Safety considerations
Potential for immune-related adverse eventsCytokine release syndrome
06
Interacting drugs
Type I Interferons (multiple subtypes)
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