Target intelligence / Profile preview

Type I Interferon Receptor Subunit 2 (IFNAR2)

Target: IFNAR2
Molecular classification: Receptor, Type I cytokine receptor

Overview

Type I Interferon Receptor Subunit 2 (IFNAR2) is a type I membrane protein and one of the two essential chains of the receptor complex for type I interferons. Upon ligand binding, the IFNAR1/IFNAR2 complex activates the JAK/STAT pathway, leading to the expression of interferon-stimulated genes involved in antiviral defense and immune modulation. Dysregulation or genetic variation can impact susceptibility to viral infections or autoimmune diseases. Modulation of type I interferon signaling has therapeutic implications across infectious disease, oncology, autoimmunity, and inflammatory disorders.

Other names: Interferon alpha/beta receptor 2Type I interferon receptor subunit 2IFN-alpha/beta R beta chain

Mechanism of action

Binding of type I interferons to IFNAR1/IFNAR2 heterodimer, activation of JAK/STAT pathway, induction of interferon-stimulated genes (ISGs).

Biological functions

Signal transductionAntiviral responseImmune modulationJAK/STAT signaling pathway

Disease associations

InfectionAutoimmune diseasesInflammatory disordersOncology

Safety considerations

Dysregulation of type I interferon signaling can lead to autoimmune disordersExcessive interferon signaling may cause inflammation and tissue damagePotential for off-target effects when modulating type I interferon signaling therapeutically

Interacting drugs

Type I interferons (alpha, beta, etc.)

1 more in the full profile.

Biomarkers

IFNAR2 expression levels may correlate with response to interferon therapyGenetic variants in IFNAR2 may predict susceptibility to viral infections or autoimmune diseases.

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