Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Type I Interleukin 1 receptor (IL-1RI)
- Target
- IL-1RI
- Molecular classification
- Receptor, Transmembrane protein, Toll-like/Interleukin-1 receptor (TIR) superfamily
01
Overview
Type I Interleukin 1 receptor (IL-1RI) is a transmembrane receptor that binds to IL-1α and IL-1β, initiating the IL-1 signaling pathway. Upon ligand binding, IL-1RI recruits IL-1RAcP to form a signaling complex, triggering downstream signaling cascades that regulate inflammation and immune responses.
- Other names
- IL1R1CD121aInterleukin-1 receptor type I
02
Mechanism of action
Ligand binding to IL-1RI initiates a signaling cascade via recruitment of IL-1RAcP and adaptor proteins, ultimately leading to activation of NF-κB and MAPK pathways and altered gene expression.
03
Biological functions
Signal transductionImmune responseInflammationRegulation of gene expression
04
Disease associations
Autoinflammatory diseasesCancerInflammation
05
Safety considerations
Increased risk of infectionInjection site reactions
06
Interacting drugs
Interleukin-1 receptor antagonist (IL-1RA)
3 more in the full profile.
Beyond the preview
Go deeper on Type I Interleukin 1 receptor (IL-1RI).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Type I Interleukin 1 receptor (IL-1RI).