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Target intelligence / Profile preview
Type I Protein Arginine Methyltransferase (PRMT Type I)
- Target
- PRMT Type I
- Molecular classification
- Enzyme, Methyltransferase, Histone modification
01
Overview
Type I protein arginine methyltransferases (PRMTs) are a subfamily of enzymes that catalyze the transfer of methyl groups from S-adenosyl-L-methionine (SAM) to arginine residues in proteins, resulting in monomethylarginine and asymmetric dimethylarginine. They play crucial roles in epigenetic regulation, transcription, RNA processing, DNA repair, and cell signaling. Dysregulation of type I PRMTs has been linked to cancer, cardiovascular disease, neurological disorders, and viral infections, making them potential therapeutic targets.
- Other names
- PRMT1PRMT2PRMT3CARM1/PRMT4PRMT6PRMT8Type I PRMTs
02
Mechanism of action
Inhibition of methylation activity
03
Biological functions
Epigenetic controlTranscription regulationRNA processingDNA repairCell cycle progressionProliferationDifferentiationSenescenceInflammation responsesAntiviral immunityCell signaling
04
Disease associations
CancerCardiovascular diseaseNeurological disordersViral infections
05
Safety considerations
Potential for off-target effects due to homology between PRMT isoformsDisruption of normal arginine methylation processes
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