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Target intelligence / Profile preview
Type II bacterial DNA topoisomerases (Type II topoisomerases)
- Target
- Type II topoisomerases
- Molecular classification
- Enzyme, Topoisomerase
01
Overview
Type II bacterial DNA topoisomerases are essential enzymes that manage the topology of DNA in prokaryotic cells. They play a critical role in processes such as DNA replication, transcription, recombination, and chromosome segregation by introducing transient double-stranded breaks into the DNA helix and passing another segment of duplex DNA through these breaks. They are validated targets for antibacterial drugs.
- Other names
- DNA gyraseTopoisomerase IVBacterial topoisomerasesTopo II
02
Mechanism of action
Inhibition of DNA gyrase or topoisomerase IV by targeting the catalytic core or ATP-binding site, leading to DNA double-strand breaks and cell death.
03
Biological functions
DNA replicationTranscriptionRecombinationChromosome segregationSupercoiling controlDecatenationDNA repair
04
Disease associations
Infection
05
Safety considerations
Development of antibiotic resistanceOff-target effects of inhibitors
06
Interacting drugs
Fluoroquinolones (e.g., ciprofloxacin)
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