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Type II DNA topoisomerase VI subunit B

Molecular classification: Enzyme, Type IIB topoisomerase

Overview

Topoisomerase VIB is a subunit of the type IIB DNA topoisomerase VI complex, crucial for managing DNA topology during replication, recombination, and chromosome segregation. It contains an ATP-binding GHKL domain that drives DNA strand passage. It is found in plants and some bacteria, algae, protists, and eukaryotes. Differences between parasite and human versions suggest potential as an antiparasitic drug target.

Other names: TopoVI-BMTOPVIBTOPOVIBL

Mechanism of action

Inhibition of ATP binding and hydrolysis, disruption of Topo VIB dimerization

Biological functions

DNA topology managementChromosome segregationMeiotic recombination initiationDNA decatenation

Disease associations

Infection (e.g., Malaria)

Interacting drugs

Radicicol

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