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Target intelligence / Profile preview
Type II NADH dehydrogenase (NDH-2)
- Target
- NDH-2
- Molecular classification
- Enzyme, Oxidoreductase, Flavoprotein
01
Overview
Type II NADH dehydrogenase (NDH-2) is an enzyme that catalyzes the transfer of electrons from NADH to quinone molecules in the electron transport chain of bacteria, fungi, plants, and protists. It does not pump protons. Absent in mammalian mitochondria, it is a promising target for antimicrobial drug development. It functions as a homodimer with FAD as a cofactor and contains distinct binding sites for FAD, NAD(H), and quinones.
- Other names
- Type II NAD(P)H:quinone oxidoreductaseAlternative NADH dehydrogenaseNdiNdhNdhA
02
Mechanism of action
Inhibition of electron flow into oxidative phosphorylation pathways
03
Biological functions
Electron transportCellular respirationEnergy generationRedox balance
04
Disease associations
InfectionMitochondrial diseases (potential therapeutic target)
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