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Target intelligence / Profile preview
Type II NADH-quinone oxidoreductase (NDH-2)
- Target
- NDH-2
- Molecular classification
- Enzyme, Oxidoreductase, Membrane protein, Monotopic membrane protein
01
Overview
Type II NADH-quinone oxidoreductase (NDH-2) is a membrane-bound enzyme that catalyzes the transfer of electrons from NADH to quinones in the respiratory chain. Unlike complex I, NDH-2 does not translocate protons across the membrane. It is found in bacteria, archaea, fungi, plants, and some protozoa but is absent from mammalian mitochondria, making it an attractive target for antimicrobial drug development. NDH-2 oxidizes NAD(P)H to regenerate NAD(P)+ and reduces quinones, which then participate further down the electron transport chain.
- Other names
- Alternative NADH dehydrogenaseNDH-IIType II NAD(P)H:quinone oxidoreductases
02
Mechanism of action
Inhibition of electron transfer from NAD(P)H to quinones
03
Biological functions
Electron transferOxidation-reductionNAD(P)H oxidationQuinone reductionCellular respirationRedox balance
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects if inhibitors lack specificityResistance development in pathogens
06
Interacting drugs
Phenothiazines
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