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Collagen type I; Collagen type III (COL1A1 (Collagen type I alpha 1 chain) and COL1A2 (Collagen type I alpha 2 chain); COL3A1 (Collagen type III alpha 1 chain))
- Target
- COL1A1 (Collagen type I alpha 1 chain) and COL1A2 (Collagen type I alpha 2 chain); COL3A1 (Collagen type III alpha 1 chain)
- Molecular classification
- Structural protein, Extracellular matrix protein, Fibrillar collagen (for Type I and III)
01
Overview
Collagen type I is the predominant protein in the dermis, forming strong fibrils that give skin its structure, tensile strength, and resilience. It is a triple-helical, fibrillar protein composed of three polypeptide chains, produced primarily by dermal fibroblasts, and is essential for tissue integrity, wound healing, and extracellular matrix architecture. Its synthesis requires vitamin C and proper enzymatic processing, and it interacts with other extracellular matrix proteins to form a stable scaffold for cellular function and tissue repair.
- Other names
- Skin collagenCollagen of the dermisType I collagen (major dermal form)Type III collagen
02
Mechanism of action
Enzymatic degradation (collagenases break down collagen); Inhibition or stimulation of collagen synthesis (by retinoids, growth factors); Stabilization or cross-linking (by agents promoting cross-links)
03
Biological functions
Structural supportExtracellular matrix formationTissue strength and resilienceWound healingCell adhesion scaffold
04
Disease associations
Skin aging (loss and fragmentation leads to wrinkles and decreased elasticity)Scarring/fibrosis (excessive or disordered collagen deposition)Ehlers-Danlos syndrome (genetic defects in collagen)Scurvy (impaired collagen synthesis due to vitamin C deficiency)Keloid/hypertrophic scarsScleroderma
05
Safety considerations
Degradation can lead to loss of skin strengthOverproduction causes fibrosis/scarringImmune reactions to exogenous collagen implants or injections
06
Interacting drugs
Collagenase (for enzymatic degradation in contractures)
3 more in the full profile.
07
Biomarkers
Collagen degradation products in serum/urine (e.g., C-terminal telopeptide)Procollagen peptidesHistological collagen density in biopsies
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