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Target intelligence / Profile preview
Thyroxine 5'-deiodinase (DIO3)
- Target
- DIO3
- Molecular classification
- Enzyme, Selenoprotein, Iodothyronine Deiodinase
01
Overview
Thyroxine 5'-deiodinase (DIO3) is an enzyme that inactivates thyroid hormones by catalyzing the removal of an iodine atom from the inner ring of T4 and T3. It is highly expressed in the placenta, fetal tissues, and neonatal tissues, playing a critical role in regulating thyroid hormone levels during development. By converting T4 to rT3 and T3 to T2, DIO3 prevents premature exposure of developing tissues to excessive thyroid hormone concentrations.
- Other names
- Type III iodothyronine deiodinaseDIOIIID3Type 3 DI
02
Mechanism of action
Catalyzes the inner ring deiodination of thyroxine (T4) and triiodothyronine (T3), converting them into inactive metabolites (rT3 and T2 respectively).
03
Biological functions
Thyroid hormone metabolismInactivation of T4Inactivation of T3Regulation of thyroid hormone levelsProtection of fetal tissues from excessive thyroid hormone action
04
Disease associations
Fetal development disordersThyroid hormone resistanceNeurological disorders
05
Safety considerations
Potential disruption of thyroid hormone balance in sensitive populations (e.g., pregnant women, neonates).
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