Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Type III secretion protein PcrV (PcrV)
- Target
- PcrV
- Molecular classification
- Protein, Type III Secretion System Component
01
Overview
Type III secretion protein PcrV is an indispensable structural regulator at the tip complex of the T3SS "injectisome" used by Gram-negative pathogens like Pseudomonas aeruginosa. It orchestrates assembly/functionality of membrane pores needed to deliver toxic effectors into host cells—a process central to pathogenesis—and serves as both a validated drug target and promising vaccine candidate due to its surface exposure/conservation among clinical isolates.
02
Mechanism of action
Inhibition of T3SS mediated effector translocation
03
Biological functions
Assembly factorRegulation of effector translocationScaffoldingImmune evasion
04
Disease associations
InfectionBacterial virulenceInflammation
05
Safety considerations
Potential for off-target effectsDevelopment of resistance
Beyond the preview
Go deeper on Type III secretion protein PcrV (PcrV).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Type III secretion protein PcrV (PcrV).