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Type III Secretion System Needle-Tip Protein V (PcrV)

Target: PcrV
Molecular classification: Protein, Type III Secretion System Component

Overview

PcrV is a key protein component of the type III secretion system (T3SS) in *Pseudomonas aeruginosa*. It forms the needle-tip complex of the T3SS translocon, facilitating infection and immune evasion. PcrV is essential for full virulence and is an attractive target for anti-infective therapies.

Other names: T3SS Needle-Tip Protein V

Mechanism of action

Inhibition of T3SS function, blocking effector translocation

Biological functions

Assembly/regulation/functioning of T3SSMediates effector translocationPore formationRegulation of PopB/PopD insertion

Disease associations

InfectionVirulenceImmune evasion

Interacting drugs

COT-143

3 more in the full profile.

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