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Collagen Type VII
- Molecular classification
- Extracellular Matrix Protein, Collagen
01
Overview
Collagen type VII is a specialized collagen protein that forms anchoring fibrils at the dermal-epidermal junction in skin and other stratified squamous epithelia. It plays a critical structural role in maintaining skin integrity and resistance to mechanical stress. Mutations or autoimmune targeting of type VII collagen lead to severe blistering diseases such as dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita.
- Other names
- Type VII CollagenCOL7A1
02
Mechanism of action
N/A
03
Biological functions
Anchoring fibril formationDermal-epidermal junction maintenanceExtracellular matrix organizationTissue integrity
04
Disease associations
Dystrophic Epidermolysis Bullosa (DEB)Epidermolysis Bullosa AcquisitaSkin blistering disorders
05
Safety considerations
Autoimmune targetingGenetic mutations leading to dysfunctional protein
06
Biomarkers
Autoantibodies against type VII collagen (Epidermolysis Bullosa Acquisita)
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