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Target intelligence / Profile preview
TYRO3 Protein Tyrosine Kinase (TYRO3)
- Target
- TYRO3
- Molecular classification
- Receptor, Receptor Tyrosine Kinase (RTK), TAM receptor family
01
Overview
TYRO3 is a receptor protein tyrosine kinase (RPTK) belonging to the TAM receptor family. It plays roles in cell survival, migration, differentiation, and immune regulation. It is activated by ligands such as Gas6 and Protein S, leading to downstream signaling via PI3K/AKT, NF-κB, and Wnt/β-catenin pathways. TYRO3 is implicated in cancer development, viral infections, and autoimmune diseases, making it a potential therapeutic target, particularly in cancer.
- Other names
- BrtDtkRSETifBruton agammaglobulinemia tyrosine kinaseTyrosine-protein kinase SKYEtk-2
02
Mechanism of action
Kinase inhibition (potential)
03
Biological functions
Cell survivalCell migrationCell differentiationImmune regulationNeuronal protectionCell proliferationSpermatogenesisImmunoregulationPhagocytosisPlatelet aggregationCytoskeleton reorganizationSignal transduction
04
Disease associations
CancerLymphocytic ChoriomeningitisRetinitis Pigmentosa 38Viral infectionsRheumatoid arthritisHepatocellular carcinoma
05
Safety considerations
Potential for off-target effects due to kinase family similaritiesImpact on immune homeostasis if broadly inhibited
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