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Target intelligence / Profile preview
Tyrosine kinase expressed in hepatocellular carcinoma (TEC)
- Target
- TEC
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme
01
Overview
Tyrosine kinase expressed in hepatocellular carcinoma (TEC) is a non-receptor tyrosine kinase that belongs to the Tec family of kinases. It is preferentially expressed in the liver and is involved in signal transduction pathways related to cell growth, differentiation, and immune function. Increased expression of TEC has been observed in hepatocellular carcinoma (HCC), suggesting its involvement in hepatocarcinogenesis. TEC also plays a role in regulating the pluripotency and differentiation of human pluripotent stem cells. While no specific clinical inhibitors exist yet, it's a potential target in cancer therapy.
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionRegulation of stem cell pluripotencyRegulation of stem cell differentiationImmune functionCell proliferation
04
Disease associations
CancerHepatocellular carcinoma
05
Safety considerations
Potential for off-target effects due to homology with other Tec family kinasesLimited understanding of the full spectrum of TEC's roles in different tissues and cell types
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