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Tyrosine Kinase Inhibitor
- Molecular classification
- Enzyme Inhibitor, Small Molecule
01
Overview
A tyrosine kinase inhibitor (TKI) is a pharmaceutical agent that blocks the activity of enzymes known as tyrosine kinases. These enzymes play a crucial role in various cellular processes, including cell signaling, growth, and division. In certain cancers, tyrosine kinases are overactive or present at abnormally high levels, contributing to uncontrolled cell proliferation. By inhibiting these enzymes, TKIs can help prevent cancer cells from growing and dividing.
- Other names
- TKI
02
Mechanism of action
Inhibition of tyrosine kinase phosphorylation by binding to the ATP-binding site or allosteric sites of the kinase domain.
03
Biological functions
Cell signaling modulationInhibition of cell growthInhibition of cell divisionRegulation of phosphorylation
04
Disease associations
CancerIdiopathic pulmonary fibrosis
05
Safety considerations
Skin rashCardiovascular issuesHypertensionProteinuriaStevens-Johnson syndromeResistance developmentMutations in kinase domains
06
Interacting drugs
Imatinib mesylate
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