Tyrosine kinase with Immunoglobulin-like and EGF-like domains 2 (Tie2)

Tie2, also known as the angiopoietin-1 receptor, CD202B, or tyrosine-protein kinase receptor TEK, is a receptor tyrosine kinase primarily expressed on vascular endothelial cells. It plays a central role in blood vessel maturation, stability, and remodeling by mediating signals from its ligands—the angiopoietins. Activation by Ang1 or high concentrations of Ang2 stimulates PI3K-Akt pathway leading to eNOS phosphorylation, nitric oxide production, enhanced cell survival, vascular quiescence, and angiogenesis. It is critical for vascular stability and endothelial cell-smooth muscle communication during venous morphogenesis. Defects in the TEK gene are associated with inherited venous malformations. In cancer patients, subpopulations of monocytes expressing Tie2 contribute to tumor neovascularization.

Other names

Angiopoietin-1 receptorTEKCD202B

Inhibition or modulation of the ANGPT/Tie2 pathway.