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Target intelligence / Profile preview
Tyrosine Kinase with Immunoglobulin-like and EGF-like Domains 2 Receptor (TIE2)
- Target
- TIE2
- Molecular classification
- Receptor Tyrosine Kinase, Receptor, TIE subfamily
01
Overview
The Tyrosine Kinase with Immunoglobulin-like and EGF-like Domains 2 Receptor (TIE2), also known as TEK, is a receptor tyrosine kinase primarily expressed on endothelial cells. It plays a critical role in vascular development, angiogenesis, and blood vessel stability by mediating signal transduction pathways regulated by angiopoietins. Dysregulation of TIE2 can lead to vascular malformations and contribute to diseases involving abnormal angiogenesis, such as cancer and diabetic retinopathy. It is considered a potential target for antiangiogenic therapies.
- Other names
- TEK
02
Mechanism of action
Inhibition of TIE2 kinase activity; Angiopoietin sequestration
03
Biological functions
Angiogenesis regulationBlood vessel stabilityEndothelial cell survivalVascular maturationBlood vessel remodelingSignal transduction
04
Disease associations
Vascular malformationsCancerDiabetic retinopathyAbnormal angiogenesis
05
Safety considerations
Potential for off-target effects due to structural similarity to other RTKsRisk of disrupting normal vascular function
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