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Target intelligence / Profile preview
Tyrosine-protein kinase 2 (TYK2)
- Target
- TYK2
- Molecular classification
- Non-receptor tyrosine kinase, Janus Kinase (JAK)
01
Overview
Tyrosine-protein kinase 2 (TYK2) is a non-receptor tyrosine kinase enzyme that mediates intracellular signaling by phosphorylating receptor subunits upon cytokine binding. It plays a central role in signal transduction for several cytokines, including interferons and interleukins, and is implicated in autoimmune diseases and cancer. Selective targeting of the TYK2 pseudokinase domain has led to the development of drugs like deucravacitinib.
02
Mechanism of action
Selective inhibition of TYK2 pseudokinase domain
03
Biological functions
Signal transductionPhosphorylationImmune responseRegulation of immune cell survivalRegulation of immune cell proliferationRegulation of immune cell differentiationRegulation of immune cell functionAntiviral immunity
04
Disease associations
Autoimmune diseasesCancer
05
Safety considerations
Potential safety benefits due to isoform selectivity compared to broader JAK inhibitors
06
Interacting drugs
Deucravacitinib
1 more in the full profile.
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