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Target intelligence / Profile preview
Tyrosine-protein kinase BTK (BTK)
- Target
- BTK
- Molecular classification
- Enzyme, Non-receptor tyrosine kinase, Tec family kinase
01
Overview
Tyrosine-protein kinase BTK (Bruton's tyrosine kinase) is a non-receptor protein tyrosine kinase that plays a central role in B-cell development, differentiation, and signaling. Mutations in the *BTK* gene cause X-linked agammaglobulinemia (XLA). Pharmacological inhibition of BTK has emerged as an effective strategy for treating various B-cell malignancies.
- Other names
- Bruton's tyrosine kinase
02
Mechanism of action
Pharmacological inhibition of BTK disrupts oncogenic BCR-mediated survival signals.
03
Biological functions
Signal transductionB-cell developmentB-cell differentiationB-cell signalingRegulation of apoptosisImmune responseMast cell activation
04
Disease associations
X-linked agammaglobulinemiaCancerB-cell malignancies
05
Interacting drugs
BTK inhibitors (e.g., Ibrutinib)
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