Target intelligence / Profile preview

Tyrosine-protein kinase BTK (BTK)

Target: BTK
Molecular classification: Enzyme, Non-receptor tyrosine kinase, Tec family kinase

Overview

Tyrosine-protein kinase BTK (Bruton's tyrosine kinase) is a non-receptor protein tyrosine kinase that plays a central role in B-cell development, differentiation, and signaling. Mutations in the *BTK* gene cause X-linked agammaglobulinemia (XLA). Pharmacological inhibition of BTK has emerged as an effective strategy for treating various B-cell malignancies.

Other names: Bruton's tyrosine kinase

Mechanism of action

Pharmacological inhibition of BTK disrupts oncogenic BCR-mediated survival signals.

Biological functions

Signal transductionB-cell developmentB-cell differentiationB-cell signalingRegulation of apoptosisImmune responseMast cell activation

Disease associations

X-linked agammaglobulinemiaCancerB-cell malignancies

Interacting drugs

BTK inhibitors (e.g., Ibrutinib)

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