Tyrosine-protein kinase EphB4 (EphB4)

Tyrosine-protein kinase EphB4 is a member of the largest subgroup of receptor tyrosine kinases, distinguished by mediating contact-dependent signaling with ephrin-B family ligands, especially ephrin-B2. Activation of EphB4 triggers forward and reverse signaling events that guide cell adhesion, migration, vascular development, angiogenesis, and heart morphogenesis. EphB4 is highly expressed in various cancers and is linked to tumor cell survival, migration, invasiveness, and the regulation of pathological angiogenesis. Targeted therapies include peptides, antibodies, and small-molecule inhibitors designed to block the EphB4-ephrin-B2 interaction or kinase activity, though care must be taken to avoid detrimental impacts on normal tissue functions

Other names

EPH receptor B4Ephrin type-B receptor 4HTKMYK1TYRO11HFASDCMAVM2LMPHM7

Inhibition of EphB4-ephrin-B2 interaction (peptides, antibodies, small molecules); Kinase inhibition (ATP-competitive inhibitors); Induction of receptor degradation (specific antibody, e.g., MAb131)