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Target intelligence / Profile preview
Tyrosine-protein kinase Fyn (Fyn)
- Target
- Fyn
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase, Src family kinase
01
Overview
Fyn is a non-receptor tyrosine kinase belonging to the Src family kinases (SFKs). It plays a crucial role in various cellular signaling pathways, including cell growth, motility, adhesion, and immune responses. While normally acting as a tumor suppressor, Fyn can contribute to oncogenic transformation and cancer progression in certain contexts, particularly in gliomas. It is also implicated in neurodegenerative diseases. Fyn phosphorylates target proteins to regulate their activity, impacting signaling cascades downstream of cell surface receptors. Inhibitors targeting its ATP-binding site are being explored for therapeutic applications in neurological disorders and cancers.
- Other names
- FYN proto-oncogene, Src family tyrosine kinasep59-FynSLKSynovial sarcoma translocation gene on chromosome 6 protein
02
Mechanism of action
ATP-binding site inhibition (for some Fyn inhibitors)
03
Biological functions
Signal transductionPhosphorylationRegulation of cell growthRegulation of cell motilityImmune responseNeuronal developmentCell adhesionCell differentiation
04
Disease associations
CancerNeurodegenerative diseaseGlioblastoma multiformeAlzheimer’s diseaseParkinson’s disease
05
Safety considerations
Potential for off-target effects due to similarity to other Src family kinasesTumor-promoting effects in some contexts despite tumor suppressor role in others
06
Interacting drugs
Staurosporine
1 more in the full profile.
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