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Target intelligence / Profile preview
Tyrosine-protein kinase JAK1 (JAK1)
- Target
- JAK1
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme
01
Overview
JAK1 is a non-receptor tyrosine kinase essential for signal transduction of various cytokines, particularly type I and type II cytokines. It plays a critical role in the JAK-STAT signaling pathway, mediating cellular responses to interferons (IFN-alpha/beta/gamma), interleukins (IL-2, IL-4, IL-6 family), and other cytokines.
02
Mechanism of action
Inhibition of JAK1 kinase activity
03
Biological functions
Signal transductionCell growth/proliferationHematopoiesisImmune response modulationInflammation
04
Disease associations
Myeloproliferative neoplasmsCancerImmune evasion
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