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Tyrosine-protein kinase Lyn (Lyn)

Target: Lyn
Molecular classification: Enzyme, Protein Kinase, Tyrosine Kinase, Src family kinase, Non-receptor tyrosine kinase

Overview

Tyrosine-protein kinase Lyn (Lyn) is a non-receptor tyrosine kinase and a member of the Src family of protein tyrosine kinases. It plays critical roles in various immune cell types and is involved in both innate and adaptive immunity, hematopoiesis, and responses to growth factors or cytokines. Lyn can function either as an activator or inhibitor within signaling cascades, making it a crucial regulator of immune cell responses. Altered Lyn activity has been implicated in autoimmune diseases and hematologic malignancies.

Other names: Lck/Yes novel tyrosine kinase

Mechanism of action

Inhibition of tyrosine kinase activity

Biological functions

Signal transductionImmune regulationCell proliferationCell survivalCell differentiationCell migrationCell adhesionRegulation of degranulationRegulation of cytokine releaseResponse to DNA damageHematopoiesisIntegrin signaling

Disease associations

Autoimmune diseasesHematologic malignanciesAcute myeloid leukemiaChronic myeloid leukemiaB-cell acute lymphoblastic leukemia

Safety considerations

Potential for immune dysregulation upon inhibitionOff-target effects due to similarity to other Src family kinases

Interacting drugs

PP2

2 more in the full profile.

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