Target intelligence / Profile preview

Tyrosine-protein kinase Met (MET)

Target: MET
Molecular classification: Receptor, Tyrosine Kinase, Enzyme

Overview

MET, also known as the hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase that plays a critical role in regulating cellular processes such as proliferation, survival, morphogenesis, and motility. The endogenous ligand for MET is hepatocyte growth factor (HGF). Mutations or amplification of MET are associated with various cancers including papillary renal cell carcinoma. Both germline mutations/SNPs and somatic mutations have been reported to drive oncogenic transformation via aberrant MET signaling.

Other names: Hepatocyte Growth Factor Receptor (HGFR)c-MET

Mechanism of action

Tyrosine kinase inhibition

Biological functions

Cell proliferationCell survivalMorphogenesisCell motilitySignal transductionTissue repairTissue regeneration

Disease associations

Cancer

Safety considerations

Aberrant MET signaling can drive oncogenic transformation

Beyond the preview

Go deeper on Tyrosine-protein kinase Met (MET).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Tyrosine-protein kinase Met (MET).

Explore the full profile