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Target intelligence / Profile preview
Tyrosine-protein kinase receptor FLT1 (VEGFR1)
- Target
- VEGFR1
- Molecular classification
- Receptor tyrosine kinase, Type IV Receptor Tyrosine Kinase, VEGFR family
01
Overview
Tyrosine-protein kinase receptor FLT1 (VEGFR1) is a receptor tyrosine kinase that belongs to the VEGFR family. It plays a crucial role in vasculogenesis and angiogenesis, both during embryonic development and in adulthood. VEGFR1 binds to VEGF-A, VEGF-B, and PlGF, and exists in both membrane-bound and soluble isoforms. The soluble isoform acts as a decoy receptor, sequestering VEGF ligands and modulating VEGFR2 signaling. VEGFR1 is implicated in various diseases, including pre-eclampsia and cancer, making it a target for anti-angiogenic therapies.
- Other names
- FLT1Vascular endothelial growth factor receptor 1
02
Mechanism of action
Tyrosine kinase inhibition; VEGF ligand sequestration (soluble isoform)
03
Biological functions
VasculogenesisAngiogenesisSignal transductionCell migrationRegulation of gene expression
04
Disease associations
Pre-eclampsiaCorneal neovascularizationCancerTumor angiogenesis
05
Safety considerations
Potential for disrupting physiological angiogenesisSide effects associated with anti-angiogenic therapies
06
Biomarkers
FLT1 variants (e.g., in non-small cell lung cancer)
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