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Target intelligence / Profile preview
Tyrosine-protein kinase receptor FLT3 (FLT3)
- Target
- FLT3
- Molecular classification
- Receptor, Tyrosine Kinase, Receptor Tyrosine Kinase (RTK), Class III receptor tyrosine kinase
01
Overview
Tyrosine-protein kinase receptor FLT3 (FLT3) is a receptor tyrosine kinase that plays a crucial role in hematopoiesis, regulating the differentiation, proliferation, and survival of hematopoietic progenitor cells. Mutations in FLT3, particularly internal tandem duplications (FLT3-ITD) and point mutations at D835, are common in acute myeloid leukemia (AML) and drive uncontrolled proliferation and resistance to apoptosis. FLT3 is a therapeutic target, and FLT3 inhibitors have been developed for AML treatment.
- Other names
- Fms-like tyrosine kinase 3Stem cell tyrosine kinase 1Fetal liver kinase-2CD135
02
Mechanism of action
Inhibition of FLT3 kinase activity, either by binding to the ATP-binding site (Type I) or preventing activation by occupying a hydrophobic region (Type II).
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalHematopoiesisGrowth factor signalingKinase activity
04
Disease associations
Acute myeloid leukemia (AML)Cancer
05
Safety considerations
Resistance to FLT3 inhibitorsOff-target effects of kinase inhibitors
06
Interacting drugs
FLT3 inhibitors (Type I and Type II)
07
Biomarkers
FLT3-ITD mutationsFLT3 D835 mutations
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