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Target intelligence / Profile preview
Tyrosine-protein kinase receptor RET (RET)
- Target
- RET
- Molecular classification
- Receptor, Tyrosine Kinase Receptor, Enzyme
01
Overview
RET (Rearranged during Transfection) is a receptor tyrosine kinase that plays a crucial role in cell signaling, particularly in the development of the nervous system and kidneys, as well as in spermatogenesis. It is activated by glial cell line-derived neurotrophic factor (GDNF) family ligands that bind to GFRα coreceptors, forming a ternary complex essential for downstream signaling. Mutations or alterations can lead to loss-of-function mutations causing Hirschsprung’s disease or gain-of-function mutations causing oncogenic activation in several cancers.
- Other names
- Rearranged during TransfectionRET proto-oncogene
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Cell proliferationNeuronal navigation/migrationCell differentiation/specializationSignal transductionKidney morphogenesis/developmentSpermatogenesis
04
Disease associations
CancerHirschsprung’s diseasePapillary thyroid carcinomaMultiple endocrine neoplasia types 2A/2BPheochromocytomaParathyroid hyperplasiaCachexia syndrome
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