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Target intelligence / Profile preview
Tyrosine-protein kinase receptor TYRO3 (TYRO3)
- Target
- TYRO3
- Molecular classification
- Receptor, Receptor tyrosine kinase, TAM family
01
Overview
TYRO3, also known as Tyrosine-protein kinase receptor TYRO3, is a member of the TAM (TYRO3, AXL, MER) family of receptor tyrosine kinases. It functions as a cell surface receptor that transduces extracellular signals into intracellular responses upon ligand binding. It plays critical roles in several physiological processes including cell survival, proliferation, migration, differentiation, neuron protection, platelet aggregation, immunoregulation, and viral entry. Overexpression or aberrant activation has been linked to various cancers.
- Other names
- TYRO3 receptor tyrosine kinase
02
Mechanism of action
No specific TYRO3-targeted drugs are currently approved or available clinically. Research continues into TAM-family inhibitors.
03
Biological functions
Signal transductionCell survivalCell proliferationCell migrationCell differentiationNeuron protectionPlatelet aggregationImmunoregulationPhagocytosisCytoskeleton reorganization
04
Disease associations
CancerLymphocytic choriomeningitisZika fever
05
Safety considerations
Aberrant activation linked to cancer progression, metastasis, chemoresistance, and EMT.No specific inhibitors targeting only TYRO3 are currently available.
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