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Target intelligence / Profile preview
Tyrosine-protein kinase receptor UFO (AXL)
- Target
- AXL
- Molecular classification
- Receptor tyrosine kinase (RTK), TAM family (Tyro3, Axl, Mer)
01
Overview
Tyrosine-protein kinase receptor UFO (AXL) is a receptor tyrosine kinase belonging to the TAM family. It plays a role in cell survival, proliferation, migration, and immune modulation. AXL is activated by its ligand GAS6, leading to downstream signaling through PI3K-AKT-mTOR, MEK/ERK, NF-kB, and JAK/STAT pathways. It is implicated in various cancers and can contribute to drug resistance. AXL also acts as an entry receptor for several viruses.
- Other names
- UFOAXL receptor tyrosine kinase
02
Mechanism of action
Tyrosine kinase receptor that, upon ligand (GAS6) binding, dimerizes and autophosphorylates, activating downstream signaling pathways like PI3K-AKT-mTOR, MEK/ERK, NF-kB, and JAK/STAT, leading to cell survival, proliferation, and migration.
03
Biological functions
Cell survivalCell proliferationCell migrationCell differentiationClearance of apoptotic cellsRegulation of innate immune responsesDampens Toll-like receptor-mediated innate immune responsesInhibition of excessive inflammationLimits dendritic cell maturation/functionModulates natural killer cell activityPlatelet activation/thrombotic response regulationHepatic regeneration supportGonadotropin-releasing hormone neuron survival/migration
04
Disease associations
CancerTriple-negative breast cancer (TNBC)Acute myeloid leukemia (AML)Non-small-cell lung cancer (NSCLC)Pancreatic cancerOvarian cancerDrug resistanceViral infection
05
Safety considerations
Potential for bypass signaling in drug resistanceUpregulation in various tumor types associated with poor prognosis
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