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Target intelligence / Profile preview
Tyrosine-protein kinase SRC (c-Src)
- Target
- c-Src
- Molecular classification
- Enzyme, Protein kinase, Tyrosine kinase, Non-receptor tyrosine kinase, Src family kinase
01
Overview
Tyrosine-protein kinase Src (c-Src) is a non-receptor tyrosine kinase that regulates various cellular processes including growth, differentiation, migration, and survival. It is activated by dephosphorylation at Tyr530 and autophosphorylation at Tyr419, leading to conformational changes and increased catalytic activity. Elevated Src activity is implicated in cancer progression.
- Other names
- SRCc-SrcProto-oncogene c-Srcpp60c-src
02
Mechanism of action
ATP-binding pocket inhibition
03
Biological functions
Signal transductionGene transcriptionImmune responseCell adhesionCell cycle progressionApoptosisMigrationCytoskeletal organizationCell growthCell differentiationCell survival
04
Disease associations
CancerColon cancerBreast cancerMyeloproliferative neoplasms
05
Safety considerations
Functional redundancy among Src family members makes assigning unique roles challenging.Potential for off-target effects due to kinase similarity.
06
Interacting drugs
Bosutinib
5 more in the full profile.
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