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Target intelligence / Profile preview
TEC proto-oncogene tyrosine-protein kinase (Tec kinase)
- Target
- Tec kinase
- Molecular classification
- Enzyme, Non-receptor protein tyrosine kinase, Tec family kinase, Proto-oncogene
01
Overview
TEC proto-oncogene tyrosine-protein kinase (Tec kinase) is a non-receptor protein tyrosine kinase encoded by the *TEC* gene. It is a member of the Tec family of kinases, expressed primarily in hematopoietic cells, and involved in various signaling pathways regulating cell proliferation, differentiation, motility, apoptosis, gene expression, and actin cytoskeleton organization. Its dysregulation is implicated in cancer and immunodeficiency.
- Other names
- TEC tyrosine kinaseTyrosine-protein kinase Tec
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionCell proliferationCell differentiationApoptosisRegulation of gene expressionActin cytoskeleton organizationImmune responseCell motilityCell migration
04
Disease associations
CancerImmunodeficiencyHematological malignancies
05
Safety considerations
Potential for off-target effects due to kinase family similarityImmune dysregulationOncogenic transformation
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