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Target intelligence / Profile preview
Tyrosine-protein kinase TEK (TEK)
- Target
- TEK
- Molecular classification
- Receptor, Tyrosine Kinase, Receptor Tyrosine Kinase
01
Overview
Tyrosine-protein kinase TEK (TEK, also known as TIE2) is a receptor tyrosine kinase primarily expressed in endothelial cells lining blood vessels. It plays a crucial role in mediating communication between endothelial cells and smooth muscle cells, directing blood vessel formation (angiogenesis), and ensuring the structural integrity of blood vessels. Upon activation by its main ligand angiopoietin-1 (ANGPT1), the receptor triggers intracellular signaling cascades that regulate endothelial cell survival, proliferation, migration, and differentiation. Mutations in *TEK* are linked to multiple cutaneous and mucosal venous malformations (VMCM). In cancer biology, Tie2 expressing monocytes can promote tumor angiogenesis.
- Other names
- TIE2Angiopoietin-1 receptorCD202B
02
Mechanism of action
Tyrosine kinase inhibition
03
Biological functions
Signal transductionAngiogenesisVascular integrityEndothelial cell survivalEndothelial cell proliferationEndothelial cell migrationEndothelial cell differentiationVascular morphogenesisVascular remodeling
04
Disease associations
Multiple cutaneous and mucosal venous malformations (VMCM)Cancer
05
Safety considerations
Potential for off-target effects due to kinase family similarities.Disruption of normal angiogenesis leading to vascular instability if inhibited systemically.
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