Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tyrosine-protein kinase Tie2 (TIE2)
- Target
- TIE2
- Molecular classification
- Receptor tyrosine kinase
01
Overview
Tie2 is a receptor tyrosine kinase primarily expressed in endothelial cells. It plays a critical role in the development, remodeling, and maintenance of blood and lymphatic vessels. Tie2 is essential for vascular stability and integrity, mediating anti-inflammatory effects and suppressing vascular leakage.
- Other names
- TEKangiopoietin-1 receptor
02
Mechanism of action
Agonists promote receptor dimerization and activation; antagonists prevent receptor activation.
03
Biological functions
Blood vessel maturationLymphatic vessel maturationVascular stabilityRegulation of vascular permeabilityAnti-inflammatory effectsSignal transduction
04
Disease associations
Vascular malformationsPrimary congenital glaucomaTumor angiogenesisAge-related macular degenerationDiabetic retinopathySepsisChronic inflammatory states
05
Safety considerations
Potential for off-target effects due to kinase domain similarity with other kinases.Dysregulation can lead to uncontrolled angiogenesis or vascular leakage.
Beyond the preview
Go deeper on Tyrosine-protein kinase Tie2 (TIE2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tyrosine-protein kinase Tie2 (TIE2).