Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)
- Target
- ROR2
- Molecular classification
- Receptor tyrosine kinase-like orphan receptor, Receptor tyrosine kinase (RTK), Type I transmembrane protein
01
Overview
Tyrosine-protein kinase transmembrane receptor ROR2 is a type I transmembrane protein and a member of the receptor tyrosine kinases (RTKs). It acts as a cell surface receptor involved in noncanonical WNT signaling, particularly mediating WNT5A signaling to regulate tissue morphogenesis. ROR2 plays essential roles in early chondrocyte formation, cartilage and growth plate development, bone and cartilage growth during embryonic development, and modulation of neurite outgrowth and branching in hippocampal neurons. Mutations or dysfunctions in the ROR2 gene/protein are associated with several developmental disorders including Robinow syndrome and Brachydactyly type B, and have been implicated in metastatic diseases. It contains a cysteine-rich domain (CRD) and a Kringle domain that are critical for ligand binding and function.
- Other names
- ROR2
02
Mechanism of action
WNT5A-dependent signal transduction, modulation of DVL phosphorylation, gene expression changes
03
Biological functions
Cell proliferationDifferentiationSurvivalMotility/migrationNoncanonical WNT signalingRegulation of tissue morphogenesisEarly chondrocyte formationCartilage developmentGrowth plate developmentBone growthCartilage growthNeurite outgrowthNeurite branching
04
Disease associations
Robinow syndromeBrachydactyly type BMetastatic diseasesSkeletal dysplasiaLimb bone shorteningSpine defectsBrachydactylyFacial dysmorphismHypoplasia/aplasia of distal phalanges/nails
05
Safety considerations
Aberrant pathway activity leading to abnormal skeletal developmentDisrupted Wnt signaling during embryogenesis
Beyond the preview
Go deeper on Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2).