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Target intelligence / Profile preview
Tyrosine-protein kinase TYK2 (TYK2)
- Target
- TYK2
- Molecular classification
- Enzyme, Non-receptor tyrosine kinase, Janus kinases (JAKs)
01
Overview
Tyrosine-protein kinase TYK2 (TYK2) is a non-receptor tyrosine kinase enzyme that plays a central role in mediating intracellular signaling for various cytokines and interferons. It associates with cytokine receptors to propagate signals by phosphorylating receptor subunits, crucial for interleukin and interferon signaling pathways. TYK2 regulates cell growth, development, migration, survival, proliferation, differentiation, and immune function. Selective inhibition of TYK2 has emerged as a therapeutic strategy for autoimmune conditions.
- Other names
- TYK2
02
Mechanism of action
Selective inhibition of TYK2
03
Biological functions
Signal transductionImmune regulationRegulation of cell growthRegulation of cell developmentRegulation of cell migrationRegulation of cell survivalRegulation of cell proliferationRegulation of cell differentiation
04
Disease associations
Autoimmune diseasesInflammationCancer-related mutations
05
Safety considerations
Achieving high selectivity remains challenging due to homology among family members' catalytic sites.
06
Interacting drugs
Deucravacitinib
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