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Target intelligence / Profile preview
Tyrosine-protein kinase TYRO3 (TYRO3)
- Target
- TYRO3
- Molecular classification
- Receptor Tyrosine Kinase, TYRO3 family, TAM Receptor
01
Overview
Tyrosine-protein kinase TYRO3 is a receptor tyrosine kinase that plays crucial roles in cell signaling related to survival, proliferation, migration, differentiation, immune regulation, and phagocytosis. It binds to ligands like GAS6 and Protein S, leading to autophosphorylation and activation of downstream signaling pathways such as PI3K/AKT and NF-kappa-B. Dysregulation of TYRO3 is implicated in cancer progression, autoimmune diseases, and viral entry.
- Other names
- BYKDTKRSESKYTIF
02
Mechanism of action
Kinase inhibition; receptor antagonism
03
Biological functions
Cell survivalCell proliferationNeuron protectionPlatelet aggregationImmunoregulationPhagocytosisSignal transduction
04
Disease associations
CancerAutoimmune diseasesViral infectionLymphocytic choriomeningitisZika fever
05
Safety considerations
Potential for immune-related adverse events due to immunoregulation roleFunctional redundancy with other TAM receptors may require multi-target approachPotential impact on platelet function
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