Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tyrosine-protein kinase with immunoglobulin-like and EGF-like domains 2 (TIE2)
- Target
- TIE2
- Molecular classification
- Receptor Tyrosine Kinase
01
Overview
TIE2 is a receptor tyrosine kinase expressed primarily in vascular endothelial cells and some monocytes. It plays a crucial role in angiogenesis, vascular development, and maintaining vascular stability by interacting with angiopoietins. Activation of TIE2 promotes endothelial cell survival, proliferation, and migration through the PI3K-Akt pathway. Mutations in TIE2 are associated with venous malformations and it contributes to tumor neovascularization.
- Other names
- TEKAngiopoietin-1 receptorCD202B
02
Mechanism of action
Ligand binding (Ang1, Ang2, Ang4) induces TIE2 dimerization and activation of downstream signaling pathways, including PI3K-Akt.
03
Biological functions
AngiogenesisEndothelial cell survivalEndothelial cell proliferationEndothelial cell migrationVascular stabilitySignal transduction
04
Disease associations
Venous malformationsTumor neovascularizationAllergic conjunctivitis (potential association)
Beyond the preview
Go deeper on Tyrosine-protein kinase with immunoglobulin-like and EGF-like domains 2 (TIE2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tyrosine-protein kinase with immunoglobulin-like and EGF-like domains 2 (TIE2).