Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
YES Proto-oncogene 1 Tyrosine Kinase (YES1)
- Target
- YES1
- Molecular classification
- Non-receptor tyrosine kinase, Enzyme, Src family kinase
01
Overview
YES proto-oncogene 1 tyrosine kinase (YES1) is a non-receptor tyrosine kinase and a member of the Src family kinases (SFKs). It plays critical roles in regulating cell growth, survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. YES1 has been implicated as an oncogenic driver, with overexpression or amplification promoting cancer cell proliferation, invasiveness, and resistance to therapy. It is a promising target for novel anti-cancer therapies, particularly for overcoming tumor therapy resistance.
- Other names
- YESTyrosine-protein kinase Yes
02
Mechanism of action
Inhibition of YES1 kinase activity to overcome drug resistance and inhibit cancer cell proliferation/survival.
03
Biological functions
Cell growthCell survivalApoptosisCell-cell adhesionCytoskeleton remodelingCell migrationCell proliferationEpithelial tight junction assemblyT-cell migrationCell cycle progression
04
Disease associations
CancerDrug resistance
05
Safety considerations
Potential for off-target effects due to similarity to other SFKsDevelopment of resistance to YES1 inhibitors
06
Interacting drugs
Chemotherapeutic drugs
3 more in the full profile.
07
Biomarkers
YES1 amplificationYES1 overexpression
Beyond the preview
Go deeper on YES Proto-oncogene 1 Tyrosine Kinase (YES1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on YES Proto-oncogene 1 Tyrosine Kinase (YES1).