Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tyrosine-protein phosphatase non-receptor type 6 (None)
- Target
- None
- Molecular classification
- Enzyme, Protein tyrosine phosphatase, Non-receptor protein tyrosine phosphatase
01
Overview
SHP-1 phosphatase is a non-receptor tyrosine phosphatase primarily expressed in hematopoietic cells. It functions as a negative regulator of cellular signaling pathways, particularly those involved in immune cell activation and proliferation. SHP-1 dephosphorylates a wide range of substrates involved in immune receptor signaling and negatively regulates key pathways including JAK/STAT, PI3K/Akt, and MAPKs. Dysregulation of SHP-1 is implicated in cancer and autoimmune diseases, making it a potential therapeutic target.
- Other names
- SHP-1PTPN6Src homology region 2 domain-containing phosphatase-1
02
Mechanism of action
Inhibition or activation of phosphatase activity depending on the disease context
03
Biological functions
Signal transductionImmune responseCell proliferationCell deathNegative regulation of JAK/STAT signaling pathwayNegative regulation of PI3K/Akt signaling pathwayNegative regulation of MAPK signaling pathway
04
Disease associations
CancerAutoimmune diseasesImmune dysregulation
05
Safety considerations
Potential for off-target effects due to broad substrate specificityRisk of immune dysregulation if SHP-1 activity is excessively modulated
Beyond the preview
Go deeper on Tyrosine-protein phosphatase non-receptor type 6 (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tyrosine-protein phosphatase non-receptor type 6 (None).